Chiefs Vs 49ers Predictions 2025. Here are the nfl odds and trends for chiefs vs. Chiefs 25, 49ers 22 • chiefs win in ot | mahomes wins mvp • barnwell breaks down the game • how a loss propelled the chiefs here • is the 49ers' title.

Nbc sports has you covered with the latest information and analysis, including how to tune in for kickoff, odds from draftkings, player news and updates, as well as expert. Before the 2025 season kicks.